CCN4 and neoplasm: We found WISP1-overexpressed tumors were more radioresistant with significantly increased tumor volume and weight than control tumors when treated with 12 Gy of radiation in three fractions (255.3928 mm3vs 154.9216 mm3, P=0.029; 0.12705 g vs 0.0687 g, P=0.0134) (Fig. 5E, 5F and 5G).