CCN4 and neoplasm: Moreover, the tumor growth inhibitory effect of fractionated radiation was further significantly enhanced when combined with anti-WISP1 antibody (fractionated radiation was performed at day 4, 8 and 12 after injection of 4 μg/mL of anti-WISP1 antibody had began at day 1 for 12 consecutive days) (409.9544 mm3vs 830.8727 mm3, P=0.0102; 0.4348 g vs 0.6882 g, P=0.0325).