However, the combination treatment with fractionated radiation and recombinant WISP1 protein (fractionated radiation was performed at day 4, 8 and 12 after injection of 2 μg/mL of WISP1 protein had began at day 1 for 12 consecutive days) induced significantly increased tumor weight compared with fractionated radiation alone (0.00275 g vs 0.00115 g, P=0.0298). This evidence concerns the gene CCN4 and neoplasm.