CCN4 and esophageal squamous cell carcinoma: We found WISP1 was highly expressed in fetal esophagus and silenced in normal adult esophagus, but it was re-expressed in 159 primary ESCC patients with 67.3 % of positive ratio compared with 7.6 % of positive ratio in matched non-neoplastic tissues (P=0.0042), suggesting that WISP1 is an oncofetal gene in ESCC (Fig. 1B and Supplementary Fig. S2A).