GPT and CDH1-related diffuse gastric and lobular breast cancer syndrome: In a phase II study conducted on 186 patients with chronic-phase CML, after 8 months of continuous dasatinib treatment, 52% and 60% of patients experienced elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, respectively.[3] A similar result is also observed in another phase II study performed on 116 patients with CML in myeloid blast crisis (MBC) or lymphoid blast crisis (LBC).