MTOR and cholangiocarcinoma: In this study, we revealed a positive correlation between ZEB1 and CCA metastasis and confirmed that FBXW7 silencing significantly increased ZEB1 expression and rapamycin treatment dramatically reversed this FBXW7 silencing induced ZEB1 expression in CCA cells, implicating that ZEB1 might be an important downstream target of FBXW7/mTOR signaling.