In tumor cells, dysregulated expression of IL-3 is the molecular basis for survival and proliferation [11, 43, 46, 49] leading to malignancies, including mast cell leukemia (MCL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). This evidence concerns the gene IL3 and chronic myelogenous leukemia, BCR-ABL1 positive.