We found that Tead-2 (TEA domain family member 2) (Fig. 3B) and Tead-4 (TEA domain family member 4) (Fig. 3D) were significantly up-regulated in the all diseased HD muscles in both mouse models, while Tead-1 (TEA domain family member 1) (Fig. 3A) and Tead-3 (TEA domain family member 3) (Fig. 3C) transcripts remained un-changed. The gene discussed is TEAD2; the disease is Huntington disease.