The mice subjected to TAC produced nearly 20%, 40%, and 60% cardiac hypertrophy, respectively, two, four, and six weeks after TAC (Fig. 1C), and we found that the short form of SIRT3 was downregulated after TAC compared with the sham controls (Fig. 1D and 1F), whereas the long form was slightly increased during mild hypertrophy but did not show obvious changes during severe hypertrophy (Fig. 1D and 1E). The gene discussed is SIRT3; the disease is cardiac hypertrophy.