On the other hand, our unpublished clinical data demonstrated that the VEGF level in serum and the phosphorylated Src expression in bone specimen from patients with osteonecrosis (hip joint replacement due to femoral head avascular necrosis) were remarkably higher than those from patients without osteonecrosis (hip joint replacement due to fracture) (Supplement 1). The gene discussed is SRC; the disease is osteonecrosis.