Specifically there is emerging evidence to support the view that these apparently disparate observations actually reflect the presence of two different processes: 1) age-related neurodegeneration in the hippocampus with tauopathy but without Aβ pathology (primary age-related tauopathy — PART); and 2) independent Aβ-associated disease which begins with the early preclinical deposition of Aβ in the neocortex followed by subsequent tau accumulation, inflammation and cognitive impairment, as would be predicted by the amyloid cascade hypothesis (Crary et al., 2014; Jack, 2014; Jack et al., 2014). Here, MAPT is linked to Cognitive impairment.