The Brown-Norway rat has been used as a model of allergen-induced BHR, mimicking features of human allergic asthma, including an early and late bronchoconstrictor response, an increase in antigen-specific IgE following active immunization, eosinophilic airway inflammation, and bronchial hyperresponsiveness following allergen challenge [42, 43]. Here, IGHE is linked to allergic asthma.