To confirm that XRN1 can be repressed by HCV during infection, the relative levels of uncapped cellular mRNA were measured in naïve Huh7.5 cells, cells infected with HCV (JFH-1 strain) for 72 hours, or Huh7.5 cells that stably harbored an HCV replicon (with the H77 strain 5’ UTR) [49]. The gene discussed is XRN1; the disease is infection.