IGFBP2 and breast cancer: In our study, the human adipokine chip test of the co-culture supernatant of MCF-7 cells and adipocytes revealed some altered proteins which are reported to be involved in the regulation of proliferation and metastasis of breast cancer cells, such as IGFBP-2, IL-6sR, IL-8, leptin, MIF, and TGF-β [26–31].