By feeding CD47 deficient mice with the same diet (10% (LF) and 60% fat (HF) diet) for same periods (16 weeks) as we did before for TSP1 deficient mice3, we found that most of the phenotypes observed in the TSP1 deficient mice undergoing HF feeding were replicated in CD47 deficient mice including reduced macrophage infiltration into adipose tissue, reduced inflammation, and improved glucose tolerance and insulin sensitivity. The gene discussed is INS; the disease is hydrops fetalis.