Moreover, plasma total cholesterol (TC) and free fatty acid (FFA) levels were significantly reduced in HF-fed CD47 deficient mice (TC (mg/dl), WT HF: 115.08 ± 7.25 vs. CD47-/- HF: 80.04 ± 7.87, p < 0.01; FFA (mEq/L), WT HF: 0.34 ± 0.01 vs. CD47-/- HF: 0.28 ± 0.02, p < 0.05). This evidence concerns the gene CD47 and hydrops fetalis.