Consistent with this concept, when all the asthmatic patients in this study were compared as a group with healthy participants, the most significant asthma discriminators were airway eosinophilia and higher levels of mast cell mediators (carboxypeptidase A3, chymase, and tryptase), IL-5, IL-13, eNO, and serum IgE but lower IFN-γ levels, a pathobiologic profile classically associated with TH2 inflammation (Fig 1, A, and see Fig E11). This evidence concerns the gene IGHE and asthma.