SLC7A11 and cancer: Since KSHV induces expression of both xCT and Emmprin in a variety of infected cell lines including PEL cells (Qin et al., 2010a,b; Dai et al., 2012, 2014a), it is probable that stabilization of the xCT/CD98/CD147 supercomplex plays a critical role not only in intracellular energy metabolism (Xu and Hemler, 2005) but also in potentiating the efflux functions of multidrug transporters, which could enhance survival of KSHV-associated cancers including PEL.