SLC7A11 and cancer: By enhancing biosynthesis of intracellular GSH, xCT also protects cancer cells from drug-induced oxidative stress by mediating detoxification and extrusion of chemotherapeutic drugs via its biophysical interactions with multidrug resistance proteins (Haimeur et al., 2002; Okuno et al., 2003; Filipits et al., 2005; Yang et al., 2006).