We and others also recently reported that overexpression of xCT induces upregulation of 14-3-3β (a downstream regulatory protein from KSHV-infected cells and KS lesions), resulting in intracellular signal transduction via MAPK and increased cytokine release, cell growth, and invasiveness (Zeng et al., 2010; Qin et al., 2013). Here, SLC7A11 is linked to Kaposi's sarcoma.