This notwithstanding, our current data in Nrxn2α and Nrxn2 KO agree with many studies that reported dysfunction of NMDAR alters synaptic plasticity (Malinow and Malenka, 2002; Zucker and Regehr, 2002; Li et al., 2009; Jung et al., 2010), and is associated with psychiatric disorders (Lau and Zukin, 2007; Li et al., 2009). The gene discussed is NRXN2; the disease is psychiatric disorder.