On the other hand, the highest predicted risk of being MTX intolerant was 85.9%, if the following predictors were present: polyarticular JIA, positive ANA, parent/patient assessment of pain of 3–6 cm, JADAS-27 ≤ 5 points, thrombocytes >350 × 109/L, ALT ≤12 IU/L and creatinine ≤50 μmol/L. The gene discussed is GPT; the disease is juvenile idiopathic arthritis.