We developed and internally validated a prediction model for MTX intolerance at 6 or 12 months after MTX start in a large JIA cohort, consisting of routine clinical variables: JIA category, JADAS-27, parent/patient assessment of pain, ANA, ALT, thrombocytes, creatinine and an interaction term between creatinine and JIA category. The gene discussed is GPT; the disease is juvenile idiopathic arthritis.