AR and hepatocellular carcinoma: AR is induced in the fibrotic liver of mice chronically treated with CCl4 and in models of acute liver damage induced by CCl4, activation of Fas and LPS administration, AR induction was also demonstrated in the liver of cirrhotic patients and rats, as well as in human HCC, suggesting that AR is also implicated in hepatic carcinogenesis9, 11, 12, 13, 14.