Interestingly, preincubation with ESI-09 was able to mimic the effects of targeted knock down of EPAC1 on cell migration, wound healing, and cell adhesion, indicative of a bona fide effect of ESI-09 on EPAC function and a potential avenue in the treatment of pancreatic cancer [97]. The gene discussed is RAPGEF4; the disease is pancreatic neoplasm.