However, the requirement of lipin-1 for the increased proliferation of cancer cells under hypoxia may not only be attributed to the formation of lipid droplets, since diacylglycerol (DAG), the direct product of lipin-1 enzymatic activity, not only is the source of triglycerides but it can also be used for the synthesis of the most abundant phospholipids, phosphatidylethanolamine (PE) and phosphatidylcholine (PC), which participate in membrane biogenesis [43]. This evidence concerns the gene LPIN1 and cancer.