Downregulated canonical pathways included those involved in arrhythmogenic, hypertrophic, and dilated cardiomyopathy signaling (e.g., Itgb6, Cacna1s, and Hadh), fatty acid metabolism, and peroxisome proliferator-activated receptor (PPAR) signaling (e.g., Acaa2, Cpt2, and Acsl6) (Supplemental Table 1). The gene discussed is ACSL6; the disease is dilated cardiomyopathy.