In a mouse experiment, only OAS2 and OASL were synergistically induced by cigarette smoke and influenza virus, whereas OAS1 and OASL2 were not induced.42 OASL also can be used as a biomarker to predict rheumatoid arthritis patients’ response to tocilizumab, the drug most commonly used to treat this disease. The gene discussed is OASL; the disease is rheumatoid arthritis.