EZH2 and neoplasm: Furthermore, EZH2 was also shown to be a direct target of miR-138 [47] where experiments on several lung cancer cell lines, as well as tissue samples from patients with NSCLC revealed that the down-regulation of miR-138 resulted in an up-regulation of EZH2 inhibiting apoptosis, G0/G1 cell cycle arrest and promoting cell proliferation and tumor invasion.