These include molecules that normally inhibit IGF-1R expression such as the tumor suppressor proteins BRCA1, p53, the Wilm’s tumor (WT1) and von Hippel-Lindau (VHL), as well as molecules that stimulate IGF-1R production such as Sp1, KLF-6 and ERα [80-86]. The gene discussed is IGF1R; the disease is neoplasm.