IGF1 and invasive breast carcinoma: Homozygotes for the non-19/non-19 CA allele with non metastatic BrCa have been found to have favorable prognostic factors and longer disease-free and overall survival [41], while HER2+ patients carrying the rare SNP rs2946834 allele have poorer prognosis and decreased event-free survival probably due to increased IGF-1 circulating levels [42].