Similarly, in our data, the minor allele of rs11589479 is associated with increased disease risk and increased expression of ADAM15. However, without knowing the allele-specific expression of ADAM15 in colon tissue, we cannot determine whether our colocalisation results reflect a similar eQTL profile in monocytes and colon, or whether expression of ADAM15 in tissue resident monocytes may itself increase inflammation at the site of disease in patients with Crohn's disease. Here, ADAM15 is linked to Crohn disease.