The major, T1D predisposing, allele of rs3825932, T, has been shown to correlate with decreased CTSH mRNA and protein expression in human B-lymphoblastoid cell lines (27), and pro-inflammatory cytokines have been shown to reduce expression of CTSH in human pancreatic islets where these cytokines cause stress and increased apoptosis of islet beta cells (27). This evidence concerns the gene CTSH and type 1 diabetes mellitus.