For example, ABT-737, ABT-263, and GX15-070 have been reported to act on Bcl-2 family members; GDC-0152, birinapant, AT-406, and HGS-1029 have been designed to antagonize cIAPs, among the most promising targets for anti-cancer agent development; and Nutlins, MI-219 and MI-77301 have been shown to antagonize murine double-minute 2 (MDM2), a critical negative regulator of p53 that promotes p53 ubiquitination and degradation [9,10]. This evidence concerns the gene TP53 and cancer.