In addition, although TRAIL is a well-known apoptosis inducer, one study showed that acidic extracellular pH converted TRAIL-induced apoptosis to necroptosis in human HT29 colon and HepG2 liver cancer cells via a process that involved RIPK1/RIPK3-dependent PARP-1 activation [138]. Here, TNFSF10 is linked to liver cancer.