Human FAT genes include FAT1, FAT2, FAT3, and FAT4, and each of these genes encodes a similar large transmembrane protein consisting of multiple extracellular cadherin domains and a cytoplasmic domain that can interact with signaling molecules, which is homologous to fat in Drosophila, which has a tumor suppressor function19, 20. Here, FAT3 is linked to neoplasm.