To gain more knowledge about insulin secretion regulation by human AT as whole, 6 genes (based on the gene ontology (http://www.expasy.org/)) of which 4 genes positively involved in the insulin secretion and two of them PCSK1 (Proprotein convertase 1 (PC1)) and GCG (glucagon) (Figure 2 C) involved in the regulation of insulin synthesis were measured in pancreas and AT with and without T2D. This evidence concerns the gene GCG and type 2 diabetes mellitus.