First, to test whether these miRNAs could inhibit expression of Mmp3, Mmp10, and Mmp13, we transfected each of the seven miRNA mimics (or miRNA inhibitors) into the murine colon cancer cell line CT26.WT and found that the miR-128, miR-134, and miR-330 mimics reduced the levels of Mmp3, Mmp10, and Mmp13 mRNAs, respectively, whereas each of the inhibitors increased Mmp3, Mmp10, and Mmp13 levels, respectively (Figure 2C). This evidence concerns the gene MMP13 and colonic neoplasm.