Since miR-128, miR-134, and miR-330 can target Mmp3, Mmp10, and Mmp13, respectively and are downregulated in the inflammation-cancer link, we next explored the functions of miR-128, miR-134, and miR-330 with respect to their contributions to the tumorigenic potential of the CT26.WT murine colon cancer cells, including their effects on the cell cycle and cell proliferation, migration, and invasion. This evidence concerns the gene DDX53 and cancer.