FANCD2 and Fanconi anemia: As shown in Figure 3, exposure of H1299 cells to AITC for 6 hours induced a robust increase in γH2AX (phosphorylated form of histone 2 variant X at Serine 139) foci (Figure 3A) and FANCD2 (Fanconi anemia, complementation group D2) foci (Figure 3B) compared to DMSO treated cells.