ALDH7A1 and asthma: Given the important role attributed to increased PDE activity in the pathobiology of asthma, these new findings highlight a heretofore-unknown mechanism whereby constitutively increased Gβγ signaling regulates the altered phenotype in asthmatic HASM cells, suggesting that interventions targeted at suppressing this Gβγ-regulated signaling mechanism may enable novel approaches to treat asthma.