UBIAD1 and Schnyder corneal dystrophy: Besides its regulated association with reductase (this study and Nickerson et al., 2013), we chose UBIAD1 for further examination owing to the observation that mutations in the UBIAD1 gene are associated with SCD, which may result from dysregulated cholesterol metabolism (McCarthy et al., 1994; Gaynor et al., 1996; Yamada et al., 1998).