EGFR and head and neck squamous cell carcinoma: Epidermal growth factor receptor (EGFR/HER1) is over-expressed in 95% of head and neck squamous cell carcinomas (HNSCC) and high levels are correlated with poor patient prognosis and decreased overall survival (Grandis et al, 1998; Ang et al, 2002), suggesting that the disease is EGFR-driven and making a strong case for targeting EGFR in HNSCC.