C5 and liver disorder: Although previous studies have demonstrated the involvement of the complement system inHCV-induced liver disease, such studies have detected the presence of other products ofthe complement pathway (Pham et al. 1995, Hillebrandt et al. 2005, Brown et al. 2010, Banerjee et al.2011), such as the membrane attack complex, as well as interactions betweenthe E1 and E2 HCV glycoproteins and between C5 and the C5a receptor.