A number of CpGs are in genes implicated in familial colorectal cancer and tumor suppression, e.g., neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS; cg07068998), adenomatosis polyposis coli (APC; cg24332422), mutated in colorectal cancers (MCC; cg06894812), breast cancer 1, early onset (BRCA1; cg19531713) (see S3 Data for enriched gene sets). This evidence concerns the gene APC and familial colorectal cancer.