Particularly, non-smokers with PON1 rs662 AA (192QQ) genotype had a significant 75% decrease in lung cancer risk (OR = 0.25, 95% CI [0.06–0.98]), but this reduction was not observed in current or ex-smokers (OR = 0.72, 95% CI [0.41–1.26]). The gene discussed is PON1; the disease is lung cancer.