PON1 and lung cancer: In lung cancer patients with one or two PON1 rs662 A (192Q) alleles, 8-OHdG and TBARS levels showed a significant positive exposure-response trend for smoking status (Ptrend = 0.007 and 0.024, respectively), but this trend was not found in lung cancer patients with the PON1 rs662 GG (192RR) genotype and controls.