Our results implicate several immunological profiles apparently specific to the origin of keratitis: IL-8 > IL-6 in patients with bacterial keratitis; IL-8 > IL-6 > IL-1β and increased frequency of circulating CD3−CD56+ NK cells in patients with Gram-negative keratitis; while IL-8 = IL-6 > IL-1β in patients with fungal keratitis. Here, CXCL8 is linked to keratitis.