EVs have been suggested as potential carriers in the intercellular delivery of misfolded proteins associated to neurodegenerative disorders, such as tau and Aβ in AD, α-synuclein in Parkinson’s disease (PD), SOD1 in amyotrophic lateral sclerosis (ALS) and huntingtin in Huntington’s disease (HD) [44,45,46]. Here, MAPT is linked to Alzheimer disease.