Transfer of OT-I Tcm-phenotype cells did not change median survival time, however, tumour development was substantially slowed (MST 27 vs 20 days; p = 0.036) and average tumour size reduced (0.449 vs 1.08 cm2; p<0.01) when PD-L1 blockade was added to Tcm-phenotype cell transfer (Fig. 4D) and in some cases this more than doubled survival time. The gene discussed is CD274; the disease is neoplasm.