Although the proportion of OT-I cells expressing LAG-3 did not differ (not shown), LAG-3 expression was reduced on OT-I T cells in spleen and tumour of αPD-L1-treated mice relative to isotype-treated controls (Fig. 6G), consistent with a reduction in the ‘exhausted’ phenotype of OT-I T cells. This evidence concerns the gene LAG3 and neoplasm.