One prominent exception occurs in B-cell follicular lymphoma where fusions between BCL-2 and the immunoglobulin heavy chain gene are regularly detected thus raising BCL-2 protein levels.5, 6, 7 More commonly, upstream signaling pathways converging at the level of the BCL-2 family are deregulated within tumor cells secondarily leading to an imbalance in the BCL-2 rheostat tilting the balance in favor of survival. The gene discussed is BCL2; the disease is neoplasm.