BCL2 and follicular lymphoma: The involvement of BCL-2 itself in neoplastic transformation was nailed in 1985 when a translocation juxtaposing the BCL-2 gene and the immunoglobulin heavy chain gene t(14;18) was regularly found in human follicular lymphoma.5, 6, 7 This was the first evidence that some oncogenes rather promote cell survival than stimulate proliferation.