Along that line, the increased expression of pro-apoptotic BAX has been correlated with an increased risk of relapse in childhood acute lymphoblastic leukemia.57 Gurova et al.58 demonstrated that clonal expansion of transformed TP53-deficient fibroblasts in vitro and in a mouse tumor model was suppressed by BCL-2 overexpression. This evidence concerns the gene BCL2 and neoplasm.