DAPK2 and cancer: Alternatively, their membranes can depolarise leading to the release of cytochrome c, an early apoptotic process.14 Using two distinct cancer cell types, namely U2OS osteosarcoma and A549 non-small cell lung cancer cells,9, 15 we show that DAPK2 depletion increases the levels of intracellular ROS, leads to mitochondrial depolarisation and impairs mitochondrial metabolism.