DAPK1 and neoplasm: Although DAPK1–3 are structurally different, both DAPK2 and DAPK3 evolved from DAPK1,31 which regulates mitochondrial integrity2 and metabolic processes.3 Given the common ancestry and sequence homology within DAPKs' kinase domains, common mechanisms of action and functional redundancy have been postulated.32 Indeed, all three have been associated with apoptotic processes and thought to be potential tumour suppressors.18