IGF2 and hepatocellular carcinoma: IGF2 is a downstream factor of IGF2BPs, especially IGF2BP2.26, 27, 28 Moreover, the MAPK/ERK and PI3K–AKT/mTOR signaling pathways are downstream factors of IGF2.24 Our results showed that in HCC cell lines, miR-216b inhibited the activity of the AKT and ERK pathways by targeting IGF2BP2.