STAT3 and neoplasm: IL-6 signaling can promote tumor initiation and progression by activating multiple intracellular signaling pathways.46 Among those, STAT3 activation seems crucial to trigger carcinogenesis.48 In earlier studies, we contributed to define the role of IL-6 or STAT3 for liver injury.11, 12 In the present work, we addressed the relevance of the hepatocyte-specific role of gp130 for liver carcinogenesis.