Proteins with ECM-binding activity are believed to be of significant importance for the initiation of a device infection, since foreign materials become, as soon as they are inserted into the body, covered by ECM material (e.g., FN, fibronectin; Fg, fibrinogen; Vn, vitronectin; Cn, collagen) (Arrecubieta et al., 2006; Mack et al., 2009). This evidence concerns the gene VTN and infection.