CCNE1 and breast carcinoma: We identified that both cyclins E1 and E2 were localised to the centrosome complexes of T-47D and MCF-7 breast cancer cells using sucrose gradient fractionation of centrosomes and western blotting (Figure 2C, and Additional file 2), consistent with previous data showing specific localisation of cyclin E1 to centrosomes by immunofluorescence [6].