Furthermore, neutrophil CD44 from patients with leukocyte adhesion deficiency (LAD) syndrome type II (due to mutations of the GDP-fucose transporter gene, resulting in complete deficiency of fucosylated selectin-ligand moieties) was unable to bind E-selectin, implicating CD44–E-selectin interactions in the pathogenesis of this disease (11). This evidence concerns the gene SELE and leukocyte adhesion deficiency.