RB1 and adrenal cortex carcinoma: A study integrating transcriptome, miRNome, copy number alterations, methylome, and whole exome sequencing data in adult ACC was recently published (66), showing that major pathways involved by mutation or homozygous deletion include beta-catenin (CTNNB1 and ZNRF3), p53/Rb signaling (TP53, CDKN2A, and RB1), and chromatin remodeling (MEN1, DAXX, ATRX, MED12, and TERT) (Table 1).