ATG5 and neoplasm: Besides Beclin1, other autophagy-related proteins such as Atg4c, Atg5, and Atg7 also were found to have tumor suppressor functions in mice models and mutations autophagy-related genes such as ATG2B, ATG5, ATG9B, ATG 12, and UVRAG have been described in gastrointestinal cancers as well (67, 68).