NOS3 and type 2 diabetes mellitus: In particular, Alvarado-Vásquez et al. have shown that human umbilical vein endothelial cells isolated from healthy newborns with a strong family history of T2DM exhibit abnormal intracellular synthesis of NO and impaired expression of the eNOS, GLUT1 and p53 genes, which are all associated with NO synthesis (Alvarado-Vásquez et al., 2007).