ATIPs are interesting AT2 partners in the context of cancer, as ATIP1 has been shown to reduce proliferation of pancreatic cancer cells (Seibold et al., 2003) whereas ATIP3, which is down-regulated in breast cancer, reduces tumor growth, and metastasis in experimental mice models (Rodrigues-Ferreira et al., 2009). This evidence concerns the gene AGTR2 and breast cancer.