ATIPs are interesting AT2 partners in the context of cancer, as ATIP1 has been shown to reduce proliferation of pancreatic cancer cells (Seibold et al., 2003) whereas ATIP3, which is down-regulated in breast cancer, reduces tumor growth, and metastasis in experimental mice models (Rodrigues-Ferreira et al., 2009). Here, AGTR2 is linked to familial pancreatic carcinoma.