Among them, intracellular proteins of the ATIP family are encoded by candidate tumor suppressor gene MTUS1. MTUS1 was shown to be down regulated in several solid tumors, including from pancreas (Seibold et al., 2003), ovary (Pils et al., 2005), head-and-neck (Ye et al., 2007; Ding et al., 2012), colon (Zuern et al., 2010), bladder (Xiao et al., 2012), and breast (Rodrigues-Ferreira et al., 2009), and ATIPs have been shown to display tumor suppressor effects (Seibold et al., 2003; Rodrigues-Ferreira et al., 2009). The gene discussed is MTUS1; the disease is neoplasm.