Although the exact mechanisms by which PAI-1 influences tumor growth and dissemination remain partially controversial, it is evident that PAI-1 exerts its effects not only on fibrinolysis but also on cell attachment, migration and angiogenesis (Andreasen et al., 1997; Dimova et al., 2004; Dellas and Loskutoff, 2005; Dimova and Kietzmann, 2008). Here, SERPINE1 is linked to neoplasm.